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Abstract
Despite recent progress in anti - breast cancer therapy, there’s still urgent need to search for newer and safer anticancer agents. Encouraged by the marked cytotoxic activity exhibited by some urea derivatives, adapting different mechanism of actions, it seemed of interest to synthesize and investigate the anti-breast cancer activity of different series of urea derivatives, with the objective of discovering novel dual HER2 / HER1 kinase inhibitor as anti - breast cancer. Thus in this study, computer aided drug design techniques were adapted, virtual screening and fragment based drug design techniques to discover urea derivative as lead HER2 / HER1 kinase inhibitor. In addition, we have synthesized series of quinazoline - 2 - ylamino - pyrimidine (cyclic guanidine), symmetric diarylurea derivatives, unsymmetric diarylthiourea derivatives, diarylsulfonylurea drivatives, aryl - heterocyclic - semicarbzide derivatives and oxadiazole derivatives as HER2 / HER1 kinase inhibitor