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Abstract
Silicosis is induced by the crystalline silicon dioxide or silica inhalation and is one of the most important occupational worldwide diseases. The incidence of silicosis is progressively increasing in industry by different industrial techniques e.g sand blasting and drilling. Green tea is a dietary constituents containing natural antioxidant endowed with biological and pharmacological activities with potential benefits to human health. The present study was undertaken to evaluate and investigate the possible protective role of green tea extract against silica induced lung fibrosis. In this study, eighty adult male albino wibstar rats were used in the present study. The animals were divided into 4 groups (20 rats each). group I (Control group), group II (Sham control), group III (Silica-group) and group IV (Silica + GTE group). The microscopic and biochemical findings of this study indicate that green tea extract treatment before silica instillation rendered relatively therapeutic effect against silica toxicity in rat. Green tea extract caused a big reduction in severity and distribution of lung damages