الفهرس 
Testicular regeneration by adipose derived stem cells in rabbit buck
AbstractOnly 14 pages are availabe for public view
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Abstract
At all stages of life, radiation and chemotherapy can have a serious negative impact on the testes. Occupational hazards in radiation treatment facilities and cancer treatments are the main ways that people are exposed to these risks, the goal of the current study was to determine if adipose-derived mesenchymal stem cells (ADMSCs) can regenerate testicular tissue after being exposed to cisplatin, which damages the testes’ structure and function... Fifteen New Zealand white rabbits were divided into three groups of five: a negative control group (no treatment), a cisplatin group (single dose of cisplatin into each testis), and a cisplatin + ADMSCs group (cisplatin injection followed three days later by an ADMSC injection). On day 45 post-treatment, serum testosterone levels were evaluated, and the testes and epididymis were collected for histological, oxidative stress examination, and epididymal sperm analysis. Cisplatin caused damage to the testicular tissue and decreased serum testosterone levels, epididymal sperm counts, and antioxidants. An antioxidant imbalance was detected due to increasing malondialdehyde (MDA) and reduced glutathione (GSH) levels in testicular tissue. The ADMSC-treated group displayed a moderate epididymal sperm count, adequate antioxidant protection, suitable testosterone levels, and enhanced testicular tissue morphology. In conclusion, ADMSCs treatment improved biochemical parameters, reduced the pathological abnormalities brought on by cisplatin, and enhanced injured testicular tissue.