الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cardiovascular mortality is the leading cause of death among patients with chronic kidney disease (CKD). Recently, there has been growing interest in the role those vascular calcifications play in the development of cardiovascular disease (CVD) in these patients.Vitamin K is involved in vascular calcification through its role as a cofactor in the carboxylation, that is, activation, of the calcification inhibitor MGP (matrix Gla protein). The main aim of this study was to determine the relation between valvular calcification in hemodialysis patients and functional vitamin K as presented by serum level 0f uncarboxylated matrix Gla protein (ucMGP) and 25(OH) vitamin D level.This study was conducted over six months and included 90 hemodialysis patients and 20 apparently healthy adults with normal kidney function age and gender matched to the HD patients. Patients enrolled in this study were from hemodialysis units of Menouf fever hospital and Sirs central hospital.The results of our present study can be summarized as follows: In present results revealed that the median MGP was significantly higher in cases (588) than controls (118). (P = 0.001).In our study the median dialysis duration for HD patients was 4 years and ranged from 0.3 - 18 years. The most frequent original kidney disease was diabetes mellitus, followed by hypertension and glomerulonephritis while the least frequent was obstetric and hereditary causes.Regarding Valvular calcifications, we found that about one-third of the patients (41.1%) had calcifications of the aortic valve, and about one-quarter had calcifications on the mitral valve (27.8%). No significant differences were noted between those with and without aortic valve calcifications regarding age, gender, BMI , and dialysis duration .We also found that the median MGP was significantly higher in those with aortic valve calcification (690) than those without (499) (P = 0.015). No significant differences were noted between those with and without aortic valve calcification regarding the rest of laboratory parameters. The most important result of the present work was the significant difference in unMGP between patients and controls. Suggesting a correlation between unMGP level and aortic valve calcifications.The present study showed that no significant correlation was noted between MGP and other parameters, including age (P = 0.806), BMI (P = 0.186), Disease duration, (p=0.077), hemoglobin (P = 0.498), albumin (P = 0.546), PTH (P = 0.854), Ca (P = 0.195), vitamin D (P = 0.606), PO4 (P = 0.520), alkaline phosphatase (P = 0.255).The current study revealed that there was highly statistically significant difference found between No VC of aortic valve and VC of aortic valve regarding MGP, there was statistically significant difference found between No VC of mitral valve and VC of mitral valve regarding MGP, there was No statistically significant difference found between No Valve calcifications and Valve calcifications regarding MGP, and there was No statistically significant difference found between Single affection, Double affection and No affection regarding MGP.