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Abstract
Methods: forty eyes with non-ischemic cystoid or diffuse edema underwent SW-FAF imaging with a cSLO prior to and after three intravitreal injections of bevacizumab and pattern of hyperautofluorescence was determined (number and total area of hyperautofluorescent spots). SD OCT was done to determine the CFT, integrity of the IS/OS junction and detect other visually significant findings. The primary outcome was to determine the changes in FAF and the secondary outcome was determining whether there is an association between baseline and post injection visual acuity and FAF findings.Results: 35 cases (87.5%) had abnormal foveal hyperautofluorescence: four showed a single spot of hyperautofluorescence (11.4%) and 31 showed multiple spots (88.6%). Pre injection the mean BCVA was best for those with no then multiple then single spots and post injection, the BCVA was best for those with multiple spots then no spots then single spots, but the differences were non significant. The total area of hyperautofluorescent spots was significantly greater for single than multiple spots both pre and post injection. On subdivision of cases into groups according to the change in their BCVA, in 23 cases the visual acuity improved, 15 remained the same and 2 cases deteriorated. The improved viusal acuity group had lower CFT, less hyperautofluorescent spots and a slightly greater total area of hyperautofluorescence but the differences were not significant. Conclusion: there are certain FAF patterns in DME, but they cannot be definitively correlated with vision or prognosis following therapy