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Abstract
Legionella pneumophila (Lp), is a gram-negative facultative intracellular bacterium that cause pontiac fever or 2Legionnaires3 disease. Human infection occurs exclusively by inhalation of contaminated aerosols. In this study, the levels of L. pneumophila in water samples were detected. Among 78 samples that were investigated no water sample was positive for L. pneumophila. Moreover, the factors that affect this bacterial growth in both planktonic form and biofilm were studied. Copper and Acinetobacter had positive effect on Lp growth while chlorine obviously had negative effect on Lp concentrations. The possibility of emergence of resistance against ciprofloxacin and levofloxacin in L. pneumophila was also studied. The molecular mechanisms of Legionella{u2019}s virulence have started being discovered, little is known about the differences between closely related strains. Hence, the complete genomes of nine selected L. pneumophila strains were compared for the purpose of finding genomic islands using the SEED database. Also, comparative genomic analysis of virulence factors and antibiotic resistance genes of all the 16 genomes of Legionella species available within the SEED subsystems was then performed. L. pneumophila species seem to be more virulent than L. non pneumophila species. On the other hand, the resistome revealed that there is a lack of strong antibiotic resistance phenotypes