الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The early diagnosis of osteoarthritis is required to do possible intervention in early stage of disease because it is one of the leading causes of disability in advance stage. Aim: For this reason, this study aimed to investigate the relationship between the various biomarker anti-cyclic citrullinated peptide (anti-CCP) levels, Serum concentrations of N-terminal telopeptide of type I collagen (NTX), as bone resorption marker, alkaline phosphatase (ALP) and osteocalcin (OC) as bone formation markers, vitamin D, Calcium and phosphrous.in patients with osteoarthritis (OA). Methods: Eighty patients with AO were included in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect Anti-CCP antibodies, NTX, OC and vitamin D. C reactive protein (CRP), phosphorus total and ionized calcium. Results: Among cases with negative anti-CCP group, NTX showed a significant positive correlation with OC, Anti-CCP, ALP, Phosphorus and a negative correlation with Vitamin D, Total calcium and CRP. Moreover, OC showed a significant positive correlation with Anti-CCP, ALP, Phosphorus, while the negative correlation appeared significantly with Vit D, total and ionized calcium.
Among cases with positive anti-CCP group, NTX showed a significant negative correlation with osteocalcin. Osteocalcin correlates negatively with vitamin D and ionized calcium. Patients in the highest quartile of serum NTX concentrations showed the fastest rate of bone loss. The sensitivity and specificity for detecting rapid bone loss were 75% and 0.75, respectively. Conclusion: Serum NTX may provide a clinically relevant serum assay to estimate bone turnover in OA patients.