الفهرس 
The correlation between macular ischemia by fundus fluorescein angiography and spectral domain optical coherence tomography findings in diabetic macular edema
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 101 |  |  |
| | | from | 101 | | |
Abstract
Background: Foveal avascular zone enlargement is considered an indication of ischemia and may contribute to macular edema. We studied the association between The OCT structural changes, and vascular changes around the fovea in FFA to define the role of these methods in the detection of ischemic diabetic maculopathy.Methods: This cross-sectional study included 35 eyes of 25 patients with ischemic and mixed diabetic maculopathy as determined by irregular margins of the FAZ in {uFB02}uorescein angiography. We measured the best-corrected visual acuity (BCVA), central macular thickness, inner retinal layer thickness and the lateral extent of inner segment{u2013}outer segment (IS-OS) disruption on SD-OCT images, as well as the FAZ to optic nerve head (FAZ/ONH) area ratio using the Image J program.Results: The FAZ/ONH area ratio was positively correlated with LogMAR BCVA but was not statistically significant (P = 0.815, r = - 0.041). The central macular thickness and the inner retinal layer thickness showed no significant correlation with FAZ/ONH area ratio (P = 0.161, 0.480 respectively). The mean horizontal and vertical extents of IS-OS disruption were not signi{uFB01}cantly correlated with FAZ/ONH area ratio (P = 0.630 and P = 0.732 respectively. The horizontal and vertical extents of IS-OS disruption showed a significant correlation with Log MAR BCVA (r = 0.798 and 0.795 respectively, P < 0.001 in both). Conclusion: In patients with diabetic retinopathy, it is not possible to predict FAZ area based solely on the measurements assessing volume and thickness or retinal structure evaluation on OCT. Consequently, at present OCT cannot replace FA in the detection of ischemic or mixed diabetic maculopathy