الفهرس 
Bioevaluation of bioactive nanosacffolds fabricated from cellulose nanocrystals and hyaluronic acid for wound dressings application
AbstractOnly 14 pages are availabe for public view
 |  | from | 223 |  |  |
| | | from | 223 | | |
Abstract
Designing of the bioactive wound dressing with ideal properties is one of the essential key factors for successful fixing for impaired wound healing. Recently, nanofibers and hydrogels have attracted considerable attention as optimal candidates for engineering and designing advanced tissue scaffolds owing to their advanced composition and structural similarities to the native the extracellular matrix (ECM) of normal skin. Hyaluronic acid (HA) based wound dressings is considered one of the bioactive wound dressings that face many obstacles that limit their clinical application, such as; poor mechanical properties and weak antimicrobial activity. In this regard, nanofiber and hydrogel wound dressings based on hyaluronic acid (HA) and polyvinyl alcohol (PVA) were developed by the electrospinning and solution casting method. Cellulose nanocrystals (CNCs) were incorporated into the developed scaffolds for improving their mechanical properties. Furthermore, the amino acid, L-arginine, was loaded into two types nano scaffolds (nanofiber (NFs) and hydrogel membrane) for enhancing the prevention of microbial infections and for accelerating the rate of wound closure. The prepared two forms of nano scaffolds (PVA/HA/CNCs/L-arginine) were instrumentally and physiochemically characterized. Also, the L-arginine release profile from the two forms of nano scaffolds was studied at physiological pH=7. Results revealed that the incorporation of CNCs (0.5%) as nanofiller improved the mechanical properties of nanofiber and hydrogel membrane, three and two folds, respectively, compared to CNC-free NFs and membranes. Moreover, introducing CNCs intro both forms of nano scaffolds increases swelling % and hydrodegradation rate. The PVA/HA/CNCs/L-arginine NFs showed sustained release of L-arginine starting with 11% after 1h, in contrary with PVA/HA/CNCs/L-arginine hydrogel membrane that was observed biphasic L- Abstract arginine release beginning with burst release of 50% after one h. NFs would ensure the sustained release of L-arginine in plasma, thus, avoiding any toxic adverse side effects