الفهرس 
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Abstract
SLE is an autoimmune disease in which organs and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. Along with a number of environmental factors, genetic factors are implicated in the occurrence of SLE. Lupus nephritis (LN) is a kidney inflammation caused by SLE. Its manifestation is diverse patterns of immune complex-mediated renal disease affecting glomerular, tubulo-interstitial, and vascular compartments, frequently associated with abnormal production of cytokines. It is a major cause of morbidity and mortality in SLE patients. Osteopontin (OPN) also called as Eta-1 is a competent protein in the extra-cellular matrix. The aim of the current study is to investigate the possible association of the osteopontin 9250 C/T (rs 1126616) single nucleotide polymorphism with development of lupus nephritis among a group of Egyptian lupus nephritis patients and to evaluate its correlation with laboratory and clinical data in addition to both activity and chronicity indices. The study results revealed that : There is statistically significant increased frequencies of OPN 9250 T/C (rs 1126616) TT, combined CT+TT genotypes and T allele in LN patients when compared with control group. However these genotypes are not associated with each of the demographic data, laboratory data, and clinical features in addition to activity and chronicity indices in all studied LN patients so these polymorphisms might be risk factors for developing SLE and LN in genetically predisposed individuals, but they do not seem to have a role in the evolution of the disease.OPN 9250 (CT+TT) genotype could be used as predictor of development of lupus nephritis in Egyptian SLE patients.Higher AI and CI could be considered as predictors of proliferative classes of renal biopsy.