الفهرس 
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Abstract
Most Hepatocellular Carcinomas (HCCs) are diagnosed at an advanced stage. However, HCC early diagnosis is complicated by the coexistence of inflammation and cirrhosis. The unsatisfactory sensitivity and specificity of Alpha-fetoprotien (AFP) for screening of early-stage HCC paved the way for new novel biomarkers to complement AFP such as AFP-L3. The aim of this study was the Evaluation of alpha fetoprotein-L3 (AFP-L3) as earlier marker in diagnosis of hepatocellular carcinoma in Egyptian patients. This study was conducted on 80 patients categorized into 2 groups; group 2 (40 patients with chronic active hepatitis) and group 3 (30 patients with HCC). HCC diagnosis was done by clinical, triphasic CT and positive US for focal lesion in addition to 20 healthy individuals as a controls (group 1). The current study showed that the level of (AFP-L3) has a high predictive value for early detection of liver cancer due to its high sensitivity compared to the currently used AFP individual levels. It can also be used to determine the severity of the disease in chronic hepatitis patients.