الفهرس 
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Abstract
Obstructive sleep apnea Syndrome (OSAS) is a breathing disorder of sleep produced by partial or complete obstruction of the upper airways; this sleep disorder is considered as a risk factor for cognitive impairment in patients with obstructive sleep apnea syndrome with its different domains in different levels of affection. Treatment with continuous positive airway pressure (CPAP), showed improvement in cognition and sleepiness; CPAP improves attention, vigilance memory executive functions and sleepiness, but deficits in learning memory and psychomotor function persist. These findings suggest that improvements in sleepiness is not always associated with improvements in cognition, and it has been suggested that the improvement of cognition could be related with duration and severity of OSAS. The aim of the study is to assess the cognitive impairment by MOCA questionnaire, in patients with obstructive sleep apnea syndrome who underwent a full night polysomnogram, and the efficacy of CPAP treatment for 3 months in improving the cognitive impairment with its different 7 domains in patients with obstructive sleep apnea syndrome. It included 60 subjects who were self-referred or physician-referred and attended to Sleep Disorder Breath Outpatient Clinic of Chest Medicine Department at Mansoura University Hospitals in the period from 2019-2021.The subjects were divided into the following groups: group A (cases): this group included OSAS patients who were diagnosed by full night polysomnogram, and MOCA Questionnaire was applied to them before and after 3 months treatment of CPAP. (n=30). group B (control): this group included subjects who do not have by polysomnogram (≥ 5 AHI + at least one of the following symptoms (eg, excessive daytime sleepiness, fatigue, or impaired cognition) or ≥ 15 AHI without symptoms). (n=30). The main results of the study revealed that: significantly higher BMI and neck circumference in OSAS group versus No OSAS group. However, there were significantly lower scores of Berlin and STOPBANG questionnaires in OSAS group versus No OSAS group. Significantly higher SpO2< 90% percentage of TST in OSAS group versus No OSAS group. However, there was significantly lower Average SpO2 in OSAS group versus No OSAS group. Also, there was significantly higher MOCA score in OSAS group 3 months after CPAP versus before CPAP use. And, there was significantly higher MOCA score in OSAS group versus No OSAS group. Conclusions: OSAS is associated with significantly more cognition impairment than Non-OSAS as assessed by MOCA questionnaire. Cognition impairment in OSAS improves significantly after 3 months of effective compliant CPAP treatment.