الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
ME is defined as a retinal thickening in one DD of the centre of the macula. It is a number of microvascular retinal changes that lead to BRB disruption, causing leakage of fluid and plasma components into the inner and outer plexiform layers. DME is a major complication of DR and a main cause of loss of vision in diabetic patients. Many modalities of treatment have been developed to treat DME either nonsurgical or surgical procedures. Nonsurgical treatments for DME have included focal and grid macular laser photocoagulation (MLP), STTA, IVTA, and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents. Surgical treatment considered vitrectomy when no response to nonsurgical treatments or in DME patients with epiretinal membrane or vitreomacular traction
Several comparative studies exist comparing PPV alone with PPV with ILM peeling. However, the indications and benefits of ILM peeling remain controversial.
This meta-analysis included 14 studies all were published between 2000 and 2019. They were RCTs – 753 eyes of participants with DME.
The mean age ranged between 54.125 and 64.7 years.
The baseline of the mean BCVA ranged between 1.077 and 0.6 log. MAR.
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Summary
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The CMT mean baseline ranged between 308.80 to 525.1 μm.
Two different techniques, PPV alone and PPV with ILM peeling This study demonstrated non statistically significant change in the mean of BCVA improvement and CMT reduction in both groups when comparing the baseline to one- and three-month follow-ups after the intervention.