الفهرس 
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Abstract
Coronavirus is a common pathogen that mostly affects the respiratory system of humans. The severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome (MERS)-CoV are two previous coronavirus (CoV) outbreaks and recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the major global pandemic of COVID 19.
SARS-CoV-2 have been the focus of many studies since its emergence that have shown that the cytokine storm play a major role in the pathogenesis of this virus. However data on the role of chemokine interferon γ-induced protein 10 (IP-10) /CXCL10 in the severity of COVID 19 are very limited.
This study aimed to correlate the levels of serum IP-10 to the severity of the disease and to determine if NK cell depletion correlates inversely with IP-10 in COVID 19 patients which suggest a potential role for IP 10 in recruitment of NK cells to `the airway epithelium contributing to the pathologic effect seen in severely ill patients.
An observational cross-sectional study was conducted on 30 COVID 19 patients attending Geriatric department of Ain Shams university Hospital, divided into 2 groups: group I included 15 moderate cases and group II included 15 severe and critical cases.
3ml EDTA anti-coagulated blood samples will be collected and the level of interferon gamma induced protein 10 (IP-10) was measured by enzyme -linked immuno sorbent assay (ELISA) using monoclonal antibodies. NK cell was identified in the sample using fluorochrome-labelled monoclonal antibodies using a six-color flowcytometer: Navieus Lettman Coulter device.
There was a significant increase in the IP-10 level in the in the severe group in comparison with the moderate group, while there was a significant decrease in decrease in NK cell count in the severe group in comparison with the moderate group, while there is significant increase in the IP-10 level in the in the severe group in comparison with the moderate group.