الفهرس 
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Abstract
The pesticides lead to pollution of the air, soil and water, which in effects on plants, animals and human public health. Uncontrolled use of pesticides results in production of free radicals and deficiency of the self-defense antioxidant system inside the cells leading to oxidative stress, which contributes to the damage of various body organs. One of the most common pesticides is methomyl carbamate which has been classified as category-1- toxicity. The exposure to methomyl exerts toxic actions on the liver, kidney, and heart. It has been suggested that hepatic oxidative status caused by methomyl results into formation of free radicals that cause the toxicity to the liver and these free radicals was extended to heart, kidney, and other organ such as spleen and lung. Medicinal plants antioxidants can ameliorate oxidative induced liver damage by reduction of lipid peroxidation and enhancement of scavenging ability of antioxidant defense system. Screening of in vitro selective antioxidant activity was conducted in this study on 10 species: (Balanites aegyptiaca Del. (Zygophyllaceae) (whole date), Amrtemisia absinthium L. (Asteraceae) (seeds), Zingiber officinale Rosc. (Zingiberaceae) (roots), Curuma Longa L. (Zingiberaceae) (roots), Citrus paradise Macfad. (Rutaceae) (fruits), Moringa Oliefera Lam. (Moringaceae) (leaves), Ammi visnaga (L.) Lam. (Apiaceae) (whole plant), Cymbopogon proximus STAPF. (Gramineae) (roots), Olea europaea L. (Olea ceae) (leaves) and Glycyrrhiza glabra Linn) of medicinal plants from local market in an attempt to find highly antioxidant extract that can be used as treating agent for hepatotoxicity induced by methomyl. Accordingly, the present study was designed to evaluate the effect of the most effective antioxidant extract on methomyl-induced hepatotoxicity in mice and its nanoform to increase the bioavailability of the extract within the body. To achieve this goal, the study was conducted as follows: firstly, preparation of plants extract, then phytochemical screening of the plants, examination of the antioxidant activity of each plant extract, preparation of Balanites nanosuspension, study of LD 50 of Balanites, the study was conducted on 11 Swiss albino mice groups (6 each). The current study showed that Balanites Aegyptiaca extract possess marked antioxidant activity without notable toxicity in experimental mice. In addition, BLT has a dose-dependent improvement in liver, heart and kidney functions in animals treated with MET. Furthermore, BLT ameliorated the antioxidants biomarkers levels in liver tissue and total antioxidant capacity. Data have also shown that BLT managed MET-induced toxicity and oxidative stress via significant induction of Nrf2 gene expression and hepatic clearance.