الفهرس 
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Abstract
Background : Vaspin in an anti-inflamatory marker while VAP-1 is a pro-inflamatory marker in chronic diseases specially psoriasis vulgaris. NLR has been shown to be useful in the assessment of clinical severity and outcomes in several chronic inflammatory diseases including psoriasis vulgaris. Patients and Methods: A fifteen-month case control study was conducted on eighty participants during the period from October 2018 until January 2020 and they were the subject of this work after taking a written consent from them to perform the study. The subjects were divided into two groups: A) Forty patients with psoriasis vulgaris as study group attending the Dermatology outpatient clinic of Mansoura University Hospitals. B) Forty age and sex matched healthy subjects as a control group. All patients were subjected to history taking, clinical examination including assessment of severity of psoriasis using PASI score and investigations (CBC &Lipid profile). Control persons who have no signs and symptoms of other disease condition were recruited from the public. The studied persons were subjected to: Detailed history Thorough general and dermatological examination Clinical evaluation of patients • 4 ml venous blood was collected from all subjects • They were divided into: 1 ml blood was put in EDTA tube for Complete blood count (CBC) 3 ml blood was be allowed to clot for 30 minutes at room temperature then centrifuged and then the serum was separated and put into Eppendorf tubes, stored frozen at -80ºc until the time of use. Results: There was highly statistically significant increase in neutrophils count and neutrophil lymphocyte ratio (p value <0.0001 &<0.001) respectively in patients in comparison with control group while no statistically significant difference as regard lymphocytic count. The level of Vaspin in patients group was statistically significantly lower than its levels in control group (p <0.001) while, the level of VAP1 in patients group was statistically significantly higher than its level in control group (p <0.001). No statistically significant difference in the Complete blood count data was found between patients with PASI level <10 and patients with PASI level ≥10 as regard hemoglobin level, Leukocyte count, Erythrocytes and platelets) except in NLR which was significantly higher in patients with PASI level ≥10 compared to patients with PASI level <10 (p<0.001) Serum Vaspin level was statistically significantly lower in patients with PASI level ≥10 than patients with PASI level<10 while serum VAP- 1 level showed no statistically significant difference between patients with PASI level <10 and patients with PASI level ≥10. Conclusion: Vaspin in an anti-inflamatory marker while VAP-1 is a pro-inflamatory marker in chronic diseases specially psoriasis vulgaris. NLR has been shown to be useful in the assessment of clinical severity and outcomes in several chronic inflammatory diseases including psoriasis vulgaris. Vaspin is significantly lower in psoriasis patients than healthy subjects. In addition, It is lower in patients with PASI level ≥10 compared to patients with PASI level <10 VAP1 is significantly higher in Psoriasis patients than healthy subjects. Neutrophil count and NLR are significantly higher in psoriasis patients. Also they are significantly higher in patients with PASI level ≥10 compared to patients with PASI level <10. Vaspin level is negatively correlated with the severity of psoriasis as when the severity of psoriasis increases the Vaspin level decreases. No significant positive correlation was found between VAP-1 and psoriasis as regard severity of the disease.