الفهرس 
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Abstract
Molecularly targeted cancer drug discovery, particularly protein tyrosine kinases (PTKs) inhibitors have been revolutionizedover the last two decades.
Bruton’s tyrosine kinase (BTK) plays a crucial role in B-cell antigen receptor (BCR) signaling, proliferation and survival. On the other hand, aberrant activation of BTK is always associated with hematologic malignancies and autoimmune diseases.
Since BTK is widely expressed in many B-cell leukaemias and lymphomas, targeting BTK by small molecules inhibitors becamean attractive idea as new treatment modalities for B-cell malignancies.
Many pyrimidines based scaffold showed potent inhibitory activity against BTK in addition to their potential in vitrocytotoxic activity in various leukemic cell lines.
The present investigation aimed to designand synthesize some novel pyrimidine derivatives as potential Bruton’s Tyrosine Kinase (BTK) inhibitors