الفهرس 
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Abstract
Inorganic Nano-Layered double hydroxide (LDH) material serves well in the catalytic fields, so it has been demonstrated a great applicability in the pharmacological fields. In the current study, we report Zn-Al LDH as adsorbent for Levofloxacin. The physical and chemical property of the prepared material before and after adsorption were monitored using X-ray diffraction, FT-IR analysis, Energy Dispersive using X-Ray (EDX), BET surface area, HRTEM, and FESEM. Density functional theory (DFT) calculations for Levo and their protonated species were studied at B3LYP/6-311G (d,p) level of theory. The removal percentage of Levo was 73.5 %. The adsorption isotherm was investigated using nine different models at pH 9; the obtained correlation coefficients (R2) by Redlich-Peterson and Toth model were 0.977. The thermodynamic parameters such as ΔS°, ΔGº and ΔH° were estimated and discussed in detail. Also, to support the adsorption research field, the applicability of the formed waste after Levo adsorption onto the Zn-Al LDH was investigated for some medical purposes. The toxicity of Levo in both normal and nanocomposite form was studied. Neither toxicological symptoms nor harmless effects were exhibited throughout the in-vivo study. The oral anti-inflammatory activity, tested using 6% formalin to produce edema in the footpad, was manifested as a significant increase by 37% in the anti-inflammatory effect of Zn-Al LDH/Levo nanocomposite compared to Levo in the normal form.
Keywords: levofloxacin (Levo), adsorption technique, Zn-Al-LDH, Anti-inflammatory, toxicity, Rats, thermodynamic study, DFT calculations.