الفهرس 
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Abstract
Objective: To investigate the potential of Dentine sialoprotein and Interleukin 1 receptor antagonist IL-1RA expressed in gingival crevicular fluid of resorping teeth as a biomarker of root resorption using Enzyme-linked immunosorbent immunoassay (ELISA). Materials and Methods: this study included Seventy-five patients that were divided into three groups each group was twenty-five patients, 1st group was orthodontic group, twenty-five patients, 15 females and 10 males, age from 13:21 years old, with 1.2:30 % orthodontically induced root resorption, 2nd group was pediatric group, 25 patients 13 females and 12 males, age from 8:11 years old, with resorping lower 2nd primary molar, 3rd group was the control group, consisted of 25 patients 16 females and 9 males, who were healthy with no medical nor dental history with age from 11:33 years. After reviewing each patient’s panoramic or pre-apical x-ray record, GCF samples were collected from 1st group from the upper central incisor, the second group from the lower primary 2nd molar, the 3rd group from upper central. The samples were analyzed to measure the levels of IL-1RA and DSP using ELISA. Results: IL-1RA showed significant difference between groups as it was significantly lower in the orthodontic group and pediatric group and higher in control group (P<0.017) DSP showed significant difference as it was higher in the orthodontic and pediatric group than the control group (P<0.0005). Conclusions: IL-1RA and DSP both showed significant difference which suggests using these two analytes as biomarkers for early diagnosis of orthodontically induced root resorption.