الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Early prediction of response in patients with breast cancer is crucial for planning surgery and assessing the effectiveness of the therapy. Routine conventional imaging including mammography and ultrasonography should be performed at the time of cancer diagnosis and following completion of NAC.
Breast imaging with mammography and ultrasound remain the standards of care for the follow-up of patients undergoing neoadjuvant chemotherapy, MRI is superior for predicting treatment response and evaluating residual disease.
Volumetric assessment in 23 patients with LABC (locally advanced breast cancer) was obtained at two time periods (before NAC and after 3 or 4 cycles of chemotherapy), using digital mammography, ultrasound and MRI,
In our study, we found that the majority of cases were able to be sized using ultrasound than using mammography as there were about 17.3% of the cases couldn’t be measured by mammography due to dense breast parenchyma and about 8.7% of cases couldn’t be sized by ultrasound due to the large size of the tumor that was out of the probe range. This defect had diminished when we used the results of the mammography and ultrasound together which had raise the sensitivity, specificity and accuracy of the results comparing to MRI results.
The ability of mammography and breast ultrasound to accurately measure residual tumor size following neoadjuvant chemotherapy compared to Breast MRI measurement of the residual tumor demonstrated sensitivity of 94.12 % and specificity of 83.33%.With high accuracy value reaching to 91.30 %. Furthermore, the use of both imaging modalities improved the accuracy of predicting a pathological response to neoadjuvant chemotherapy in a greater percentage of cases than use of either modality alone. For surgical decision-making, the use of ultrasound in combination with mammography can predict amount of residual disease and complete pathological response.
IN Conclusion
Even that the MRI is proved to be of high accuracy to detect residual tumor, sonomammographic imaging is widely founded and presented in most oncology centers as well as hospitals with oncology departments and considered as a cost-effective imaging modalities than the MRI with sensitivity and specificity near to that of MRI.