الفهرس 
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Abstract
Introduction: Hepatocellular carcinoma is the fifth most common cancer worldwide. The majority of HCC patients are diagnosed at advanced stage, and the therapeutic options for HCC are very limited. Therefore, searching for additional therapy is strongly recommended. It has been shown that, turmeric extract, black pepper, curcumin and taurine revealed therapeutic effect against hepatocarcinoma cells propagated ex-vivo and in vivo using experimental animal model In addition piperine was found to increase the absorption and the bioavailability of curcumin. Patients and Methods: Mononuclear leukocytes (MNLs) and serum were obtained before and after three and six weeks of treatment from HCC patients (N. = 30) divide into two groups. CPT group (N. = 15) treated curcumin, piperine, and taurine and TBT group (N. = 15) treated turmeric extract, black pepper, taurine taken daily for six weeks compared to untreated healthy control (N.= 30). Sera Cytokines levels for IL- 10, IL- 6, IL-8, TNF- α, IFN-γ and TGF- α and immunophenotypic characterization of MNL were determined. Results: Regarding, cytokine evaluation in sera of the patients post- treatment did show that, IL-10 was significant decrease, on contrary there was significant increase in IFN-γ level compared to baseline (before treatment) for CPT group. For TBT group showed significant decrease in IL- 10 level and increase and TNF- α and TGF- α level. As for immunophentyping of MNL of the patients under investigation; there were highly significant differences in CD4+%, CD8+%, CD4+CD25+%, and CD8+CD25+% after treatment compared to baseline (untreated patients) in CPT group and also for TBT group except in CD4+ % showed no significant difference. Conclusion: curcumin, piperine and taurine are promising therapeutic natural derived agents in treatment of patients suffering from hepatocellular Carcinoma.