الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 142 |  |  |
| | | from | 142 | | |
Abstract
ultiple Sclerosis (MS) is a chronic neurological disorder affecting central nervous system. However the etiology is not well understood, but most probably multifactorial involvement is the most convenient theory till now (McKay et al., 2017).
Etiology of multiple sclerosis, and whether this varies from one patient to the next, still remains elusive, but the disease is thought to arise in genetically susceptible individuals, with random events and environmental factors influencing disease penetrance (Dendrou et al., 2015).
In the present study, 111 Egyptian patients were included in our sample from MS Unit, Neurology department at Ain Shams University Hospital with inclusion and exclusion criterion aiming to eliminate factors that cause MS like symptoms in different medical and neurological conditions, serum vitamin D and lipid profile will be determined for all the patients.
Our study showed a high prevalence of vitamin D insufficiency and low prevalence of dyslipidemia among MS patients as 81.08% of the study population have insufficient vitamin D levels, 21.62% have high levels of TC, 0.04%
M
Summary and Conclusion
93
have high levels of TG, 10.81% have high LDL levels and 18.01% have low HDL levels.
Regarding the serum vitamin D level, ARR and number of relapses during last 2 years were significantly lower in sufficiency group compared to insufficiency group; with significant statistical difference (P-value 0.005 and 0.043 respectively). Serum vitamin D levels were lower in females compared to males with significant statistical difference (P-value 0.011).
However, there was no significant association with the rest of possible determinants in our study like age, age at onset of illness, disease duration, EDSS and MRI findings.
As regard the lipid profile, patients with higher levels of TC, TG and LDL have longer disease duration with a significant correlation (P-value 0.038, 0.025 and 0.01 respectively), while there was no significant association with age, age at onset of illness nor gender.
Patients with higher total number of relapses have higher levels of TC and LDL with a significant correlation (P-value < 0.001 and 0.003 respectively) while have lower level of HDL (P-value 0.003). This correlation remain significant only with TC after linear regression analysis.
Summary and Conclusion
94
Regarding number of relapses during last 2 years, there was a positive significant correlation with TC and LDL while a negative significant correlation with HDL (P-value < 0.001 for each).
Regarding the degree of disability, TC and TG levels were significantly higher in moderate to severe group compared to mild group; with a significant statistical difference (P-value 0.001 for each) while HDL levels were significantly lower in moderate to severe group with a significant statistical difference (P-value < 0.001).
Regarding the T2 lesion load, Patients with confluent lesions have higher levels of TC and TG with significant statistical difference (P-value 0.001 and 0.002 respectively).
As regard correlation between serum vitamin D level and lipid profile, there was a significant correlation negatively between vitamin D and TC levels (P-value 0.002) and positively between vitamin D and HDL levels (P-value 0.028)