الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
MS is an autoimmune disease characterized by inflammation , demyelination and axonal degeneration leading to interruption of myelinated tracts of the CNS. The cause of MS is still unknown but some environmental factors and genetic risks may contribute for developing the disease.MMP9 is one of the gelatinases subgroup of MMPS family .The human MMP9 is located at chromosome 20q13.12 .MMP9 plays an important role in degradation of basement membrane, breakdown of BBB and MBP cleavage producing inflammation and degradation of nerve axons in the CNS. A single nucleotide polymorphism at position -1562 is caused by a C to T substitution , This substitution prevents the binding of a nuclear transcription repressor protein to this region of the MMP9 gene promotor ,being associated with increased MMP9 expression.