الفهرس 
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Abstract
Curcumin has been identified as the active principle of turmeric (Curcuma longa Linn) that has been traditionally used in medicine and cuisine in India and other Asian countries. The objective of this study was to evaluate the effect of aqueous extract of Curcumin on aging in rats. This study was carrying out on 60 male rats of a Sprague Dawley type. 15 young rats weighing 200-250gm and 45 old rats weighing 400-450 gm were fed and cared for at a temperature of 22 °C, the moisture content of 30-70% and then divided the rats into four groups. At the end of the experimental period, the rats of each treated group were fasted overnight, and sacrificed under slight halothan anaesthesia. Blood was collected by cardiac puncture. Serum were separated by centrifugation at 4000 r.p.m for 10 min for determination of lipid profile and antioxidants level. IL_6, TNF- ⍺ are also measured. Brain tissue is taken for dopamine, Another part of brain for determination of HDAC and COX-2 gene expression using RT-PCR. The results showed that there were statistical significant differences between control and curcumin groups in the levels of lipid profile ,blood antioxidants, neurological markers and dopamine .In case of sciatic and brain tissue pathology, there was an obvious difference between control and curcumin group as curcumin stimulates neurogenesis and nerve tissue regeneration.