الفهرس 
REVIEW OF LITERATURE
Rheumatic heart diseaseOnly 14 pages are availabe for public view
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Abstract
Rheumatic fever is a delayed immunologically mediated autoimmune sequela of throat infection by group A β-hemolytic streptococci, and it is a multisystem inflammatory disease that can affect different tissues including synovial joints and cardiac valves.
The current hypothesis of chronic rheumatic heart disease is that following acute RF attack, there will be a continuous chronic inflammation of cardiac valves and patients with more intense inflammatory reaction have a more rapid progression of valvular dysfunction.
The Aim of the work was to study the relation between serum levels of long acting penicillin and the inflammatory markers C - reactive protein and Interleukin-6 in patients with chronic rheumatic heart disease. And this would help to detect the real efficacy of long acting penicillin in secondary prevention of rheumatic heart disease.
Eighty patients from rheumatic heart disease patients coming to Ain Shams university hospitals’ outpatient clinic for rheumatic fever prophylaxis by regular long acting penicillin administration were subjected to the study. Patients were divided into to 2 groups: group A ; 70 patients with rheumatic heart disease already on long acting penicillin ,and group B ;10 patients with rheumatic heart disease who have not started long acting penicillin yet in addition to group C ; control group of
10 healthy individuals not known to have rheumatic heart disease and long acting penicillin has a strong effect in secondary prevention of chronic rheumatic heart disease and its inflammatory mediators.