الفهرس 
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Abstract
HCV infection is one of the main causes of chronic liver disease worldwide. In Egypt, which has the highest prevalence of chronic HCV, the treatment poses an economic burden on the government (El-Zanaty and Way 2008).
Ogawa et al. (2015) study showed that non-invasive fibrosis assessments (FibroScan, APRI, FIB-4) are valuable in predicting SVR by prior partial or null responders in telaprevir-based triple therapy.
So this study aimed at assessing role of liver fibrosis using APRI, FIB4, and GUCI -as predictors of liver fibrosis- to assess the virological response to Sofosbuvir-based regimen therapy in Egyptian patients with chronic HCV infection.
This study enrolled (80) patients with chronic HCV infection who received anti-viral treatment as part of the national program for combating viral hepatitis in Egypt. They were divided into group (1) and (2).
group (1) included (50) patients who maintained a virological level undetectable by PCR at week 16 and week 24 from treatment start (cured).
group (2) included (30) patients who failed to maintain a virological level undetectable by PCR at week 16 and/or week 24 from treatment start.
Patients underwent anti-viral treatment (Sofosbuvir + Daclatasvir) for 12 consecutive weeks according to the “The National Program for Combating Viral Hepatitis” protocol at this time.
1. History taking: age, gender, DM, HTN, smoking, past medical history, drug history, hepatic encephalopathy, oesophageal varices, weight loss.
2. A laboratory evaluation: Patients were subjected to pre-treatment laboratory workup. Pre-treatment blood samples were collected.
3. Radiology: Abdominal ultrasound especially on the liver.
After data collection, scores (AST-to-platelet ratio index, FIB4 score, and GUCI) were calculated according to the given equations
Our study showed that regarding (gender Age, Smoking, HTN, FBS, HbA1C, WBC, Hb, Creatinine, PCR, Child score, Child sub-grouping), there were a significant statistical difference between both studied groups.
But, regarding (PLT and Albumin), there was a significant statistical difference between both studied groups.
While regarding (DM, PAUS, AST, ALT, Total bilirubin, AFP, APRI, Lok index, FIB-4, GUCI, CDS), there was a significant statistical difference between both studied groups.