الفهرس 
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Abstract
TBI is defined as damage to the brain resulting from external mechanical force leading to temporary or permanent impairment of brain functions. It can be classified according to GCS into mild (GCS ≥13), moderate (GCS=9-12) and severe (GCS ≤8).TBI is a major cause of morbidity and mortality worldwide, especially in children and young adults. Neurological damage following TBI is often referred to secondary injuries, including PTS, which has its own consequences such as hypoxia, increased intracranial pressure and cardiac arrhythmias which may worsen the clinical outcome. PTS can be classified as immediate (within 24 hours of injury), early (within 7 days of the injury) or late (more than 7 days after the injury). A total of 135 patients with moderate or severe TBI were selected from Mansoura University Emergency Hospital trauma patients. The studied patients were randomly and equally divided into 3 groups (n=45) according to the medication used to prevent PTS occurrence for 1 week after trauma: group 1 given PHT, group 2 given LEV and group 3 (control) where no medications given for prophylaxis. The aim of the study was to compare between PHT and LEV regarding role in PTS prophylaxis and their adverse effects. The most common mode of trauma was RTA, followed by FFH, struggle and then falling down. There were no significant differences between the 3 study groups regarding the modes of trauma.