الفهرس 
LASIK ComplicationsOnly 14 pages are availabe for public view
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Abstract
This prospective study was conducted upon 34 eyes of 17 patients aiming to subjective and objective evaluation of the effect of Brimonidine tartrate 0.2% ophthalmic solution on improving post-LASIK pupil diameter, contrast sensitivity, aberrations and symptoms of night vision difficulties.
Emmeropic patients, aging from 20 to 35 years, with significant night vision complaints after LASIK surgery were enrolled in this study. Medical history, Surgical history, drug history were taken from all patients to rule out other causes of night vision difficulties. A validated questionnaire covering symptoms of NVD was given to all patients on enrollment and repeated after 2 months of regular Brimonidine tartrate use.
A comprehensive ophthalmic examination was performed. All patients received 1 DROP of Brimonidine tartrate 0.2 % ophthalmic solution in both eyes and were asked to apply 1 DROP in each eye daily at night time for 2 months. Testing was performed before drops instillation, 30 minutes, 4 hours after drops instillation and 2 months after treatment.
Testing of patients was performed by quantitative Pupil size measurement in photopic and scotopic conditions using Zywave built in pupillometer, Contrast sensitivity testing using Pelli-Robson chart in standardized lighting conditions, Aberrometry using Orbscan III linked Zywave III aberrometers.
Brimonidine tartrate 0.2% ophthalmic solution was effective in reducing scotopic and photopic pupil size after 30 minutes, 4 hours and 2 months from its instillation with the maximum decrease occurred at 30 minutes post-instillation. There was a little increase in the mean photopic and scotopic pupil diameter 2month after treatment in comparison to the readings at 4 hours after drops instillation, but still it was less than baseline and 30 minutes post-instillation readings. There was a significant improvement in contrast sensitivity 30 minutes, 4 hours after Brimonidine instillation and after 2 months of daily Brimonidine use.
Brimonidine showed a significant effect in reducing mean spherical aberrations and RMS of total eye aberrations at 30 minutes, 4 hours and 2 month of once daily drops instillation. Patients showed a significant satisfaction after 2 month treatment period with Brimonidine tartrate ophthalmic solution in reducing night vision difficulties with 7 patients showed their will to continue on Brimonidine tartrate daily use for a longer period to achieve better visual results.