الفهرس 
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Abstract
Background: Guillain-Barré syndrome (GBS) is a common neurological disorder that is characterized by symmetrical weakness of the limbs which reaches a maximum severity within 4 weeks. According to a recent classification, Bickerstaff’s brainstem encephalitis (BBE) can also be included into GBS variants (. Also, previous reports from western countries showed that acute inflammatory demyelinating polyneuropathy (AIDP) is the most common subtype of GBS. However, the proportion of different subtypes of GBS and their prognosis varied significantly among different regions.
Aim of the work: To study contributing factors that may affect poor and good prognosis of GBS cases.
Patients and methods: This prospective observational study included 50 patients who are diagnosed with GBS and recruited from neuropsychiatry department of Nasser Institute Hospital. Aiming at identifying predictors of outcome in GBS.
Results: We found Hughes score is highly predictive factor of functional outcome with high statistical significance. We also identified some clinical predictors of important impact on functional outcome as Antecedent GIT infection, cranial nerve affection, need for ventilation which have negative impact on GBS prognosis.
Conclusion: GBS had a male predominance with age 5-80 commonly affected. The most common electrophysiological subtype was axonal followed by demyelinating. High GBS score on admission associated with poor outcome. Hyponatremia, hypoalbuminemia were associated with poor outcome. RBS HbA1C level were not related to outcome. High CSF protein and cytoalbuminous dissociation are independent predictors of poor outcome.
Recommendations: Early identification of poor outcome predictors that negatively affect the functional outcome. Early intervention with appropriate treatment if possible to achieve better functional outcome, reduce level of disability.