الفهرس 
Chapter (one) Introduction and literature reviewOnly 14 pages are availabe for public view
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Abstract
In this study we divided the work into two parts;
The first part: physical study on CoQ10 which used as drug into DPPC liposomes
The molecular interaction between DPPC liposomes and CoenzymeQ10 (CoQ10 as drug) has been examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). It has been observed using DSC that the mixtures of DPPC and CoQ10 show a single peak, which indicates that they are miscible. The results obtained indicate that the greater effect of CoQ10 upon the incorporation into negatively charged liposomes in comparison with the other liposome formulations. The incorporated CoQ10 is probably associated with the lipid bilayers, interacted to a large extent with them, and perturbed them which results in the strong broadening and shift to lower temperature 94 C of the major characteristic endothermic peak of pure DPPC that exists at 105 C. It has been shown by means of FTIR that the incorporation of CoQ10 into DPPC induced a conformational change in the polar region of DPPC as deduced from the changes observed in the frequencies of the phosphate (PO2 -) group in the polar head of DPPC and C=O group near the head group of phospholipids in interfacial region.
The second part: The ophthalmological, histopathological, Biochemical and biophysical studies after applied CoQ10 which used as drug into DPPC liposomes on lenses of rates
To apply a new medical application for the present work, the tested formulas were prepared as eye drops to treat a model of cataract in experimental animals. The biological studies confirmed and explained by the present biophysical studies which showed the higher encapsulating ratio of negative molecules of DPPC liposomes than other charges.
The ophthalmological and histopathological studies revealed that negatively charged followed by neutral DPPC encapsulating CoenzymeQ10 seems to be more successful in reducing the progress of cataract than positively charged DPPC encapsulating CoenzymeQ10. However, CoenzymeQ10 alone proved to be more effective in treatment cataract than other groups.
Biochemical and biophysical studies also had confirmed that negatively charged followed by neutral DPPC encapsulating CoenzymeQ10 were more effective in improving the lens soluble proteins levels and total antioxidant capacity than positively charged DPPC encapsulating CoenzymeQ10. In addition, CoenzymeQ10 alone proved to be more effective in improving their levels than other groups.
In conclusion, the data presented here clarify, to a certain extent, the molecular interactions of CoQ10 with membrane systems and may additionally contribute to a better understanding of CoQ10 physiologic properties and the development of therapeutic advanced systems.