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Abstract
The role of caffeic acid in modulating miRNA expression related to diabetic nephropathy in rats.
Aya Shaaban Ragheb Shaaban, Biochemistry department, Faculty of Science, Ain Shams University.
Diabetic Nephropathy is considered the most common cause of end-stage renal disease (ESRD) around the world that accounts for the high rate of mortality in diabetic patients.
However persistent microalbuminuria was the most known biomarker in diabetic nephropathy, there are some limitations in using albuminuria as a marker of diabetic nephropathy (DN) therefore, it became necessary to find alternative biomarkers that help in diagnosis of DN earlier and identify its progression risk.
MicroRNA profiling is a promising strategy for diagnosis of diabetic nephropathy. The potential of miRNAs to be biomarkers for kidney diseases has been investigated. Several miRNAs have been reported to have functions related to DN.
The present study was conducted on 48 rats of 6 different groups. It was proved by qPCR that miRNA-636 expression level is related to diabetic nephropathy as diabetic nephropathy group showed upregulated levels of miRNA-636 expression which upon treatment with caffeic acid showed down-regulated levels in protected and treated groups.
Caffeic acid has role in many biological activities; it could be a good lead compound for new drug development.
Also the kidney function parameters showed high defects in diabetic nephropathy group that improved by administration of caffeic acid in protected and treated groups.
In addition, lipid profile of diabetic nephropathy group showed great impairment but caffiec acid administration in protected and treated groups improved this impairment.
Finally the histopathological studies on kidney tissues showed the positive effect of caffeic acid on modulating the damages caused by diabetic nephropathy.
So as, we can use miRNA-636 as a novel biomarker for detection of diabetic nephropathy, we look forward for the possibility of using caffeic acid to minimize the appearance of diabetic complications on the kidney.
Key words: Diabetic nephropathy, miRNA, caffeic acid