الفهرس 
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Abstract
Influenza virus is an RNA virus infects the respiratory tract causing many symptoms including nasal secretions, cough, muscle pain. It may threat life in immunocompromised patients. It infects about 3-5 million people yearly with approximately 500,000 deaths reported worldwide. A wide variety of thiadiazoles and its bioisosteres with potential antiviral activity is known in the literature. The present study involves the design and synthesis of new thiadiazole derivatives and its bioisosteres in order to find more efficient and safe antiviral agents with fewer side effects. The adopted reactions afforded different new 31 final compounds that were not mentioned in the available literature. Structure elucidation of the newly synthesized compounds was achieved through micro analytical analyses and spectroscopic methods.Molecular modeling studies were carried out using MOE software to predict the expected affinity of the most active compounds with 4E5H protein. Further pharmacological screening was done to determine the effect of the newly synthesized compounds on influenza virus.