الفهرس 
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is a malignant neoplasm derived from the stratified squamous epithelium of the oral mucosa. It accounts for more than 90% of malignant neoplasms of the oral cavity. Aim of the study: This study aimed to evaluate any correlation between immunohistochemical expression of syndecan-1 and both of available clinical data and different histopathological grades of the studied OSCC cases. Method: immunohistochemical staining for syndecan-1 was performed in 40 archived paraffin blocks of OSCC, the scoring of syndecan-1 expression was carried out on two parameters: 1) percentage of positive tumor cells involved and 2) staining intensity. Results: Microscopical examination of OSCC cases revealed the different histological features of differentiation and distribution of OSCC cells, classified according to WHO into Well (21 cases), Moderately (13 cases) and poorly differentiated tumors (6 cases). Statistical analysis demonstrated observed between syndecan-1 expression and each of tumor size, clinical stages, histopathological grades and recurrence. No significant difference was found regarding either age, site, lymph node metastasis in relation to syndecan-1 expression its cytoplasmic expression pattern in the studied OSCC cases was more likely to be associated with a worse prognosis. Conclusions: The result of the present study suggest a possible role of syndecan-1 in early stages of oral carcinogenesis as its downregulation is associated with high grades of OSCC cases as well as recurrence, thus it could be benefit as a marker for prediction of poor prognosis in this type of malignancy, moreover, it might also be helpful to select OSCC cases suitable for adjuvant chemotherapy before surgical interventions.