الفهرس 
Description of CamelsOnly 14 pages are availabe for public view
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Abstract
Hend Abou Elazm ELsayed Ibrahim. Gene Expression of some
Economic Traits Related to Heat Stress in Camel, Unpublished Ph.D.
Thesis, Department of Genetics Faculty of Agriculture, Ain Shams
University, 2016.
Camels have a number of adaptations to help them to survive the
most successfully in such dry and arid climates. Camels have an
exceptional ability to adapt to desert lifestyle with remarkable
physiological characteristics such as fluctuating body temperature from
34°C to 41.7°C throughout the day, tolerating water loss greater than
30%, and capability of drinking 100 liters of water in as little as 10
minutes. In the present study, global methylation was assessed in camels
exposed to two climatic changes; cold and heat. Data obtained indicated
the differences in the methylation of these animals, which, in turn, reflects
a difference in gene expression patterns based on epigenetics. In winter
season, the majority of samples enrolled in this study were
hypermethylated while in summer season, half of the samples were
hypomethylated and the rest were hypermethylated where there was a
significant difference between samples in winter and summer with pvalue < 0.05 (p = 0.020). Meanwhile, a significant difference between
samples in winter and summer on the level of gene expression of (leptin
and IGF) with p-value < 0.05 (p = 0.000) has been obtained. The seasonal
variation affected the levels of plasma proteins such as Immunoglobulin
(γ-globulin), Post-Transferrin, Transferrin (β-globulin) and α-globulin
(slow and fast). This study was concerned mainly with to genes (lipten
and IGF), which are related to milk production, as an example of
economic traits. The results obtained indicated that the reduced
temperature (winter) has caused the whole genome of camels to
hypomethylate while the elevated temperature caused hypermethylation
of the whole genome. Real time- RCR data confirmed the epigenetics
data with regards the two genes under study. We concluded that heat
stress could regulate the gene expression on the epigenetics level