الفهرس 
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Abstract
Hepatitis C virus (HCV) infection is a serious global health problem that affects 180 million people worldwide. It is estimated that three to four million people are infected with HCV every year. Hepatitis C virus causes acute and chronic hepatitis which can eventually lead to permanent liver damage and hepatocellular carcinoma (Shors, Teri , 2011).
HCV infection is considered a systemic disease because of involvement of other organs and tissues concomitantly with liver disease. Among the extrahepatic manifestations, neuropsychiatric disorders have been reported in up to 50% of chronic HCV infected patients (Gragnani et al., 2014).
About one-third of patients with chronic HCV infection with compensated cirrhosis have cognitive dysfunction. The aetiology of cognitive dysfunction in HCV infection is unknown. One potential contributor is cytokine dysregulation associated with prolonged immune system activation. Cognitive dysfunction in patients with chronic hepatitis C virus infection is a distinct form of minimal hepatic encephalopathy. In fact, the majority of HCV-positive patients, irrespective of the grading of liver fibrosis, display alterations of concentration, attention, executive function, and memory when they are evaluated by suitable neuropsychological tests. HCV replication in the brain may play a role in the pathogenesis of neuroinflammation.
Patients with cirrhosis frequently show mild extrapyramidal signs secondary to alterations of basal ganglia circuitry.
HRQOL is becoming a key component in the estimation of the disease impact and outcome, evaluation of any therapeutic intervention (Ashrafi et al., 2012).
In this study, we tried to evaluate the common neuropsychiatric disorders in patients with chronic liver diseases, and their effects on patients’ quality of life.
This study included 80 participants (60 patients with chronic liver diseases and 20 healthy controls matched for age, sex, and education level) enrolled from the outpatient clinics and the in-patient department of the Tropical Medicine and Gastroenterology, Minia University Hospital. The controls selected randomly from outpatient clinics and relatives of the patients admitted to our department.