الفهرس 
Oxidants and antioxidantsOnly 14 pages are availabe for public view
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Abstract
Oxygen metabolism is altered in DS patients. In recent years it has been hypothesized that an
increase in oxidative stress in DS patients accounts for the appearance of different diseases such
as atherosclerosis, accelerated cell aging, cellular mutagenecity and neurologic disorders that
often occur in these patients.
The present study was aimed to study the level of glutathione peroxidase enzymes and selenium in
the serum ofDS patients as indicators of antioxidative metabolism.
It was conducted in the Genetic Unit, Pediatric department of Ain Shams university Hospital. It
included 40 patients with DS (21 males and 19 females) their ages ranged between 1 year and 11
years (mean age 3.83 ± 2.95) and 10 age & sex matched healthy
cases as controls. To all studied cases, full history and thorough clinical examination, abdominal
ultrasound, echocardiography, cytogenetic study and serum antioxidants including (GPX) and Se
level were done.
The results revealed a significant increase in GPX activity in DS patients than the control
group (609.43 ± 116.19 vs 504.20 ±
40.07 U/L), there was no significant difference in GPX level with sex or age difference and also
there was no significant difference between both cases with and without CHD. Regarding selenium
level, there was no significant difference between DS patients and control group with no sex or age
difference in selenium level and there was no significant difference between both cases with and
without CHD.
There was no significant difference between both cases above and below weight and height centile
regarding GPX and Se level. There was a significant negative correlation between GPX and Se in
plasma. The central role of Se in GPX provides a focus for intervention, as Se supplementation may
be able to up regulate GPX activity to restore some balance with the over expressed SOD.