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العنوان
Pancreaticoduodenectomy with major vascular resection and reconstruction /
المؤلف
Abdallah, Ahmed Mohammed Ahmed El-Sayed.
هيئة الاعداد
باحث / أحمد محمد أحمد السيد عبدالله
مشرف / ناظم محمد على شمس
مشرف / سمير عبداللطيف زيدان
مشرف / تامر فادي يوسف يعقوب
مشرف / فايز شحتو فايز محمود
الموضوع
Vascular Reconstruction. Venous Resections. Pancreatic Adenocarcinoma.
تاريخ النشر
2016.
عدد الصفحات
online resource (209 pages) :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
جراحة
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of General Surgery
الفهرس
Only 14 pages are availabe for public view

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Abstract

Introduction: Adenocarcinoma of the pancreas is the most common pancreatic exocrine neoplasm and accounts for 75%-85% of all pancreatic malignancies and the fourth leading cause of cancer-related death with an overall 5-year survival rate of less than 4%. Surgical resection remains the only potentially curative treatment but it is only possible for 15%-20% of patients with pancreatic adenocarcinoma. As about 40% of patients have locally advanced non-resectable disease and the remaining patients have metastatic disease. Therefore, about 80%-85% of patients are treated palliatively or chemotheraputicaly. In the absence of metastatic disease, which would preclude resection, determination of vascular invasion is an important parameter for estimating pancreatic cancer resectability. Venous resections and reconstructions are increasingly performed as the technique is feasible and reliable. Patients and methods: In this study we performed different techniques of surgical resection with and without the need of vascular resection and reconstruction for total number of 44 patients during the period between December 2012 -July 2015 with retrival of data of another six patients from the medical database from June 2008-december 2012. Results: We described the results following standard pancreatic resection, resection of borderline resectable pancreatic tumors without and with vascular resection and reconstruction in terms of operative findings, postoperative morbidity and mortality, survival and recurrence rates. Summary and conclusion: venous resection and reconstruction techniques in borderline resectable pancreatic cancer although associated with significantly higher operative time and blood loss, it can be performed safely in intermediate volume oncology center with higher albeit non significant intra-operative blood transfusion, morbidity, and mortality with comparable hospital stay. Also, our results show a trend toward shorter albeit non significant mean overall and disease free survival with the vascular resection technique comparing with standard pancreatectomy however higher than that of palliative therapies.