الفهرس 
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Abstract
The involvement of CMV in hepatocellular carcinoma (HCC) is not totally defined till now. The aim of this work is to study the prevalence of CMV in HCC patients and its correlation to hepatitis B virus (HBV) and hepatitis C virus (HCV) related HCC carcinogenesis. Forty hepatic disease patients were involved 10 (25%) of them were Not suffering from HCC and 30 with HCC (75%) and its complications. Different investigations have been Performed in the serum of all patients. These measurements were HCV RNA, HBV DNA and CMV-DNA both using Real- Time PCR technique. CMV, AFP and ANA using ELISA technique. Finally SGOT and SGPT using conventional clinical analysis techniques. Concerning HCC +ve patients 73.4% of them were CMV –ve and 26.6% were CMV +ve, while 16.7% of them were HCV –ve and 83.3% were HCV +ve and 50% of them were HBV –ve and HBV +ve. Concerning HCC –ve patients 80% of them were CMV –ve and 20% were CMV +ve, while all were HCV –ve and HBV –ve. High AFP concentration was observed in 93.4% of HCC +ve patients. In conclusion both HBV& HCV and AFP were found to be highly specific risk factors in HCC patients (P< 0.0001), while CMV viral activities were not a risk factor to HCC patient (P< 0.673).