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Abstract
Gastrointestinal cancer is a major medical and economic burden worldwide. In recent years, tremendous progress has been made in our understanding of the pathobiology and molecular biology of gastrointestinal cancers. Yet, despite this progress, the clinical management of these diverse and challenging neoplasms remains difficult. This is particularly true once these cancers metastasize. Numerically, cancer affecting the gastrointestinal tract is the most common of all human malignancies, affecting patients worldwide with varying frequencies. For example, in developed countries colorectal cancers are extremely common whereas hepatocellular cancer predominates in other areas of the world. Their aetiology is mainly related to correctable and preventable lifestyle habits; namely diet (including obesity), physical activity, alcohol and tobacco intake, and sanitation. Prevention and/or treatment of Helicobacter pylori infection would significantly reduce the prevalence of gastric cancer.